The role of KCC2 in hyperexcitability of the neonatal brain

BACKGROUND: The hyperpolarizing activity of γ-aminobutyric acid A (GABA(A)) receptors depends on the intracellular chloride gradient that is developmentally regulated by the activity of the chloride extruder potassium (K) chloride (Cl) cotransporter 2 (KCC2). In humans and rodents, KCC2 expression c...

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Udgivet i:Neurosci Lett
Main Authors: Raol, Yogendra H., Joksimovic, Srdjan M., Sampath, Dayalan, Matter, Brock A., Lam, Philip M., Kompella, Uday B., Todorovic, Slobodan M., González, Marco I.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584761/
https://ncbi.nlm.nih.gov/pubmed/32860887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2020.135324
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