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Stereoselective syntheses of 3-dehydroxynaltrexamines and N-methyl-3-dehydroxynaltrexamines

Methodology is presented for the synthesis of 6α/β−3-dehydroxynaltrexamines and 6α/β-N-methyl-3-dehydroxynaltrexamines. A stereoselective route is provided for each target compound while a novel one-pot method for the synthesis of 6α/β−3-N-methyl-3-dehydroxynaltrexamines is also explored. These resu...

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Publicado en:Tetrahedron Lett
Main Authors: Li, Mengchu, St. Onge, Celsey M., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584067/
https://ncbi.nlm.nih.gov/pubmed/33100417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2020.152379
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