Maternal Adenine-Induced Chronic Kidney Disease Programs Hypertension in Adult Male Rat Offspring: Implications of Nitric Oxide and Gut Microbiome Derived Metabolites

Maternal chronic kidney disease (CKD) during pregnancy causes adverse fetal programming. Nitric oxide (NO) deficiency, gut microbiota dysbiosis, and dysregulated renin-angiotensin system (RAS) during pregnancy are linked to the development of hypertension in adult offspring. We examined whether mate...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Hsu, Chien-Ning, Yang, Hung-Wei, Hou, Chih-Yao, Chang-Chien, Guo-Ping, Lin, Sufan, Tain, You-Lin
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583952/
https://ncbi.nlm.nih.gov/pubmed/33008046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197237
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