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Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Isomerization reactions are fundamental in biology. Lactate racemase, which isomerizes L- and D-lactate, is composed of the LarA protein and a nickel-containing cofactor, the nickel-pincer nucleotide (NPN). In this study, we show that LarA is part of a superfamily containing many different enzymes....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Desguin, Benoît, Urdiain-Arraiza, Julian, Da Costa, Matthieu, Fellner, Matthias, Hu, Jian, Hausinger, Robert P., Desmet, Tom, Hols, Pascal, Soumillion, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583248/
https://ncbi.nlm.nih.gov/pubmed/33093595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74802-6
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