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Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion

The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, b...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Desguin, Benoît, Soumillion, Patrice, Hols, Pascal, Hausinger, Robert P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878509/
https://ncbi.nlm.nih.gov/pubmed/27114550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600486113
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