GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance

Skeletal muscle is an important tissue responsible for glucose and lipid metabolism. High-fat diet (HFD) consumption is associated with the accumulation of bioactive lipids: long chain acyl-CoA, diacylglycerols (DAG) and ceramides. This leads to impaired insulin signaling in skeletal muscle. There i...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Kojta, Iwona, Zabielski, Piotr, Roszczyc-Owsiejczuk, Kamila, Imierska, Monika, Sokołowska, Emilia, Błachnio-Zabielska, Agnieszka
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583033/
https://ncbi.nlm.nih.gov/pubmed/33036203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197369
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