Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction

BACKGROUND: Disordered folliculogenesis is a core characteristic of polycystic ovary syndrome (PCOS) and androgen receptors (ARs) are closely associated with hyperandrogenism and abnormalities in folliculogenesis in PCOS. However, whether the new AR binding partner phosphoglycerate kinase 1 (PGK1) i...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Xia, Sun, Changfa, Zou, Kexin, Li, Cheng, Chen, Xiaojun, Gu, Hangchao, Zhou, Zhiyang, Yang, Zuwei, Tu, Yaoyao, Qin, Ningxin, Zhao, Yiran, Wu, Yimei, Meng, Yicong, Ding, Guolian, Liu, Xinmei, Sheng, Jianzhong, Yu, Chuanjin, Huang, Hefeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581881/
https://ncbi.nlm.nih.gov/pubmed/33096483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103058
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