Frequent KIT mutations in skin lesions of patients with BRAF wild-type Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is characterized by mutations of the RAS-RAF-MAPK signaling pathway. We analyzed MAP2K1, NRAS and KIT mutation incidence in skin lesions of BRAF wild-type (wt) LCH patients. We evaluated the occurrence of MAP2K1, NRAS and KIT mutations in seven LCH and one indeter...

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Publicado en:Virchows Arch
Autores principales: Tóth, Béla, Kiss, Norbert, Hársing, Judit, Kárpáti, Sarolta, Csomor, Judit, Bödör, Csaba, Tímár, József, Rásó, Erzsébet
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2020
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581584/
https://ncbi.nlm.nih.gov/pubmed/32372223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00428-020-02820-w
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