Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice

PURPOSE: Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Ov...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Landowski, Michael, Grindel, Samuel, Shahi, Pawan K., Johnson, Abigail, Western, Daniel, Race, Adrienne, Shi, Franky, Benson, Jonathan, Gao, Marvin, Santoirre, Evelyn, Lee, Wei-Hua, Ikeda, Sakae, Pattnaik, Bikash R., Ikeda, Akihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2020
Témata:
Retinal Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581492/
https://ncbi.nlm.nih.gov/pubmed/33064130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.12.16
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