Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the retina as well as pathologies observed in age-dependent retinal diseases, suggesting that the responsible gene...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lee, Wei-Hua, Higuchi, Hitoshi, Ikeda, Sakae, Macke, Erica L, Takimoto, Tetsuya, Pattnaik, Bikash R, Liu, Che, Chu, Li-Fang, Siepka, Sandra M, Krentz, Kathleen J, Rubinstein, C Dustin, Kalejta, Robert F, Thomson, James A, Mullins, Robert F, Takahashi, Joseph S, Pinto, Lawrence H, Ikeda, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117855/
https://ncbi.nlm.nih.gov/pubmed/27863209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19264
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