Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

The proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as Alzheimer's disease (AD) and prion disease. Colony stimulating factor 1 receptor (CSF1R) is critically involved in regulating microglial proliferation,...

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Pubblicato in:Front Immunol
Autori principali: Obst, Juliane, Simon, Emilie, Martin-Estebane, Maria, Pipi, Elena, Barkwill, Liana M., Gonzalez-Rivera, Ivette, Buchanan, Fergus, Prescott, Alan R., Faust, Dorte, Fox, Simon, Brownlees, Janet, Taylor, Debra, Perry, V. Hugh, Nuthall, Hugh, Atkinson, Peter J., Karran, Eric, Routledge, Carol, Gomez-Nicola, Diego
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580706/
https://ncbi.nlm.nih.gov/pubmed/33162994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.579000
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