Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata

Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects of the crude extract of a South African medicinal plant, Cotyledon orbiculata,...

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Publicat a:Front Oncol
Autors principals: Makhafola, Tshepiso Jan, Mbele, Mzwandile, Yacqub-Usman, Kiren, Hendren, Amy, Haigh, Daisy Belle, Blackley, Zoe, Meyer, Mervin, Mongan, Nigel Patrick, Bates, David Owen, Dlamini, Zodwa
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580256/
https://ncbi.nlm.nih.gov/pubmed/33163396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.547392
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