Enhanced Analgesic Effects and Gastrointestinal Safety of a Novel, Hydrogen Sulfide-Releasing Anti-Inflammatory Drug (ATB-352): A Role for Endogenous Cannabinoids

Aims: The covalent linking of nonsteroidal anti-inflammatory drugs to a hydrogen sulfide (H(2)S)-releasing moiety has been shown to dramatically reduce gastrointestinal (GI) damage and bleeding, as well as increase anti-inflammatory and analgesic potency. We have tested the hypothesis that an H(2)S-...

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Dettagli Bibliografici
Pubblicato in:Antioxid Redox Signal
Autori principali: Costa, Soraia K.P.F., Muscara, Marcelo N., Allain, Thibault, Dallazen, Jorge, Gonzaga, Larissa, Buret, Andre G., Vaughan, David J., Fowler, Christopher J., de Nucci, Gilberto, Wallace, John L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2020
Soggetti:
Forum Original Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578177/
https://ncbi.nlm.nih.gov/pubmed/32064887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2019.7884
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