A3 A PROOF-OF-CONCEPT, PHASE 2 CLINICAL TRIAL OF THE GI SAFETY OF A HYDROGEN SULFIDE-RELEASING ANTI-INFLAMMATORY DRUG (ATB-346)

BACKGROUND: Hydrogen sulfide (H(2)S) is a naturally occurring mediator produced by intestinal bacteria and various eukaryotic cells, which can exert protective and analgesic effects. ATB-346 is a H(2)S-releasing derivative of naproxen. In animals, ATB-346 produces negligible gastrointestinal (GI) da...

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Bibliografiske detaljer
Udgivet i:J Can Assoc Gastroenterol
Main Authors: Wallace, J L, Nagy, P, Feener, T, Allain, T, Ditrói, T, Vaughan, D, Muscara, M, de Nucci, G, Buret, A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Oral Presentations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512241/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.002
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