Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide

(−)-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (−)-11-hydroxy-Δ-9-tetrahydrocannabinol ((−)-11-OH-Δ-9-THC), which is psychoactive, and to (−)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC-COOH), wh...

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Vydáno v:Int J Legal Med
Hlavní autoři: Hassenberg, Christoph, Clausen, Florian, Hoffmann, Grete, Studer, Armido, Schürenkamp, Jennifer
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578173/
https://ncbi.nlm.nih.gov/pubmed/32808050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00414-020-02387-w
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