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Strength of tonic T cell receptor signaling instructs T follicular helper fate decisions

T follicular helper (Tfh) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives initiation of their developmental program remains unclear. Studies suggest a T cell antigen receptor (TCR)-dependent mechanism may be responsible for the earliest Tfh-fate decisi...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Bartleson, Juliet M., Milam, Ashley A. Viehmann, Donermeyer, David L., Horvath, Stephen, Xia, Yu, Egawa, Takeshi, Allen, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578106/
https://ncbi.nlm.nih.gov/pubmed/32989327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0781-7
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