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A Novel “Cut And Paste” Method for In Situ Replacement of cMyBP-C Reveals a New Role for cMyBP-C in the Regulation of Contractile Oscillations

RATIONALE: Cardiac myosin binding protein-C (cMyBP-C) is a critical regulator of heart contraction, but the mechanisms by which cMyBP-C affects actin and myosin are only partly understood. A primary obstacle is that cMyBP-C localization on thick filaments may be a key factor defining its interaction...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Napierski, Nathaniel C., Granger, Kevin, Langlais, Paul R., Moran, Hannah R, Strom, Joshua, Touma, Katia, Harris, Samantha P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577522/
https://ncbi.nlm.nih.gov/pubmed/32078438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315760
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