Symmetrical arrangement of positively charged residues around the 5-fold axes of SAT type foot-and-mouth disease virus enhances cell culture of field viruses

Field isolates of foot-and-mouth disease viruses (FMDVs) utilize integrin-mediated cell entry but many, including Southern African Territories (SAT) viruses, are difficult to adapt to BHK-21 cells, thus hampering large-scale propagation of vaccine antigen. However, FMDVs acquire the ability to bind...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Chitray, Melanie, Kotecha, Abhay, Nsamba, Peninah, Ren, Jingshan, Maree, Sonja, Ramulongo, Tovhowani, Paul, Guntram, Theron, Jacques, Fry, Elizabeth E., Stuart, David I., Maree, Francois F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577442/
https://ncbi.nlm.nih.gov/pubmed/32991636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008828
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