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Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse
We generated an NOD/Shi-scid-IL2Rγ(null) (NOG) mouse deficient for the Fcer1g and Fcgr2b genes (NOG-FcγR(−/−) mice), in which monocytes/macrophages do not express activating (FcγRI, III, and IV) or inhibitory (FcγRIIB) Fcγ receptors. Antibody-dependent cellular cytotoxicity (ADCC) by innate immune c...
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| Udgivet i: | Front Immunol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7577188/ https://ncbi.nlm.nih.gov/pubmed/33117338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.532684 |
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