Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LS(A)P) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Vimberg, Vladimir, Cavanagh, Jorunn Pauline, Novotna, Michaela, Lenart, Jakub, Nguyen Thi Ngoc, Bich, Vesela, Jana, Pain, Maria, Koberska, Marketa, Balikova Novotna, Gabriela
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577164/
https://ncbi.nlm.nih.gov/pubmed/32816732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00666-20
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