Removal of Remdesivir’s Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo. Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU)...

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發表在:Antimicrob Agents Chemother
Main Authors: Lê, Minh Patrick, Le Hingrat, Quentin, Jaquet, Pierre, Wicky, Paul-Henri, Bunel, Vincent, Massias, Laurent, Visseaux, Benoit, Messika, Jonathan, Descamps, Diane, Mal, Hervé, Timsit, Jean-François, Peytavin, Gilles
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577145/
https://ncbi.nlm.nih.gov/pubmed/32868327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01521-20
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