Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

Enterobacteriaceae that produce metallo-β-lactamases (MBLs) are an emerging threat to public health. The metallo-β-lactamase inhibitor (MBLi) ANT2681 inhibits the enzymatic activity of MBLs through interaction with the dinuclear zinc ion cluster present in the active site that is common to these enz...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Das, Shampa, Johnson, Adam, McEntee, Laura, Farrington, Nicola, Kirby, Adam, Unsworth, Jennifer, Jimenez-Valverde, Ana, Kolamunnage-Dona, Ruwanthi, Bousquet, Justine, Alibaud, Laethitia, Sable, Carole, Zalacain, Magdalena, Everett, Martin, Hope, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577127/
https://ncbi.nlm.nih.gov/pubmed/32778549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01076-20
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