Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

In Alzheimer’s disease (AD), microglia are affected by disease processes, but may also drive pathogenesis. AD pathology-associated microglial populations have been identified with single-cell RNA-Seq, but have not been validated in human brain tissue with anatomical context. Here, we quantified myel...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Swanson, Molly E. V., Scotter, Emma L., Smyth, Leon C. D., Murray, Helen C., Ryan, Brigid, Turner, Clinton, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576851/
https://ncbi.nlm.nih.gov/pubmed/33081847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01047-9
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