Deletion of CD38 and supplementation of NAD(+) attenuate axon degeneration in a mouse facial nerve axotomy model

Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD(+)) and is a candidate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Takaso, Yuji, Noda, Masao, Hattori, Tsuyoshi, Roboon, Jureepon, Hatano, Miyako, Sugimoto, Hisashi, Brenner, Charles, Yamamoto, Yasuhiko, Okamoto, Hiroshi, Higashida, Haruhiro, Ito, Makoto, Yoshizaki, Tomokazu, Hori, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576594/
https://ncbi.nlm.nih.gov/pubmed/33082370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73984-3
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