A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages, and Lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity

Elevated expression of E2F1 in adipocyte fraction of human visceral adipose tissue (hVAT) associates with a poor cardiometabolic profile. We hypothesized that beyond directly activating autophagy and MAP3K5 (ASK)–MAP kinase signaling, E2F1 governs a distinct transcriptome that contributes to adipose...

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Dades bibliogràfiques
Publicat a:Diabetes
Autors principals: Maixner, Nitzan, Pecht, Tal, Haim, Yulia, Chalifa-Caspi, Vered, Goldstein, Nir, Tarnovscki, Tania, Liberty, Idit F., Kirshtein, Boris, Golan, Rachel, Berner, Omer, Monsonego, Alon, Bashan, Nava, Blüher, Matthias, Rudich, Assaf
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2020
Matèries:
Obesity Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576574/
https://ncbi.nlm.nih.gov/pubmed/32732304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1231
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