A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages, and Lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity

Elevated expression of E2F1 in adipocyte fraction of human visceral adipose tissue (hVAT) associates with a poor cardiometabolic profile. We hypothesized that beyond directly activating autophagy and MAP3K5 (ASK)–MAP kinase signaling, E2F1 governs a distinct transcriptome that contributes to adipose...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Maixner, Nitzan, Pecht, Tal, Haim, Yulia, Chalifa-Caspi, Vered, Goldstein, Nir, Tarnovscki, Tania, Liberty, Idit F., Kirshtein, Boris, Golan, Rachel, Berner, Omer, Monsonego, Alon, Bashan, Nava, Blüher, Matthias, Rudich, Assaf
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576574/
https://ncbi.nlm.nih.gov/pubmed/32732304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-1231
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