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A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes

The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We used an informatics-based approach to develop a transcriptional signature of β-cell GA stress usin...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Bone, Robert N., Oyebamiji, Olufunmilola, Talware, Sayali, Selvaraj, Sharmila, Krishnan, Preethi, Syed, Farooq, Wu, Huanmei, Evans-Molina, Carmella
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576569/
https://ncbi.nlm.nih.gov/pubmed/32820009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0636
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