A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes

The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We used an informatics-based approach to develop a transcriptional signature of β-cell GA stress usin...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Bone, Robert N., Oyebamiji, Olufunmilola, Talware, Sayali, Selvaraj, Sharmila, Krishnan, Preethi, Syed, Farooq, Wu, Huanmei, Evans-Molina, Carmella
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2020
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576569/
https://ncbi.nlm.nih.gov/pubmed/32820009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0636
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