VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress

Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage. VMAT2 plays a role in modulating insulin release by regulating dopamine levels in the pancreas, although the exact mechanism remains elusive. We found that VMAT2 expression in β-cells specifically inc...

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Detalles Bibliográficos
Publicado en:Diabetes
Autores principales: Sakano, Daisuke, Uefune, Fumiya, Tokuma, Hiraku, Sonoda, Yuki, Matsuura, Kumi, Takeda, Naoki, Nakagata, Naomi, Kume, Kazuhiko, Shiraki, Nobuaki, Kume, Shoen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2020
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576560/
https://ncbi.nlm.nih.gov/pubmed/32826296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0207
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