Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity

Cell-cycle entry relies on an orderly progression of signaling events. To start, cells first activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb. Hours later, cells inactivate APC/C(CDH1) and cross the final commitment point. However, many cells...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Liu, Chad, Konagaya, Yumi, Chung, Mingyu, Daigh, Leighton H., Fan, Yilin, Yang, Hee Won, Terai, Kenta, Matsuda, Michiyuki, Meyer, Tobias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576148/
https://ncbi.nlm.nih.gov/pubmed/33082317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18966-9
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