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Synthesis of an acyl-acyl carrier protein synthetase inhibitor to study fatty acid recycling

Fatty acids are essential to most organisms and are made endogenously by the fatty acid synthase (FAS). FAS is an attractive target for antibiotics and many inhibitors are in clinical development. However, some gram-negative bacteria harbor an enzyme known as the acyl-acyl carrier protein synthetase...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Currie, Madeline F., Persaud, Dylan M., Rana, Niralee K., Platt, Amanda J., Beld, Joris, Jaremko, Kara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575536/
https://ncbi.nlm.nih.gov/pubmed/33082446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74731-4
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