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Synthesis of an acyl-acyl carrier protein synthetase inhibitor to study fatty acid recycling

Fatty acids are essential to most organisms and are made endogenously by the fatty acid synthase (FAS). FAS is an attractive target for antibiotics and many inhibitors are in clinical development. However, some gram-negative bacteria harbor an enzyme known as the acyl-acyl carrier protein synthetase...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Currie, Madeline F., Persaud, Dylan M., Rana, Niralee K., Platt, Amanda J., Beld, Joris, Jaremko, Kara L.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575536/
https://ncbi.nlm.nih.gov/pubmed/33082446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74731-4
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