Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins

INTRODUCTION AND OBJECTIVE: Cytochrome P450 enzymes are the major drug-metabolizing enzymes in humans and the importance of drug transport proteins, in particular P-glycoprotein, in the variability of drug response has also been highlighted. Activity of cytochrome P450 enzymes and P-glycoprotein can...

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Detalhes bibliográficos
Publicado no:Drug Saf
Main Authors: Rollason, Victoria, Mouterde, Médéric, Daali, Youssef, Čížková, Martina, Priehodová, Edita, Kulichová, Iva, Posová, Helena, Petanová, Jitka, Mulugeta, Anwar, Makonnen, Eyasu, Al-Habsi, Abir, Davidson, Robin, Al-Balushi, Khalid K., Al-Thihli, Khalid, Cerná, Marie, Al-Yahyaee, Said, Černý, Viktor, Yimer, Getnet, Poloni, Estella S., Desmeules, Jules
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575470/
https://ncbi.nlm.nih.gov/pubmed/32851583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-020-00983-8
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