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Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction

Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. The present study investigates the effects of the heat shock protein 90 inhibitor Luminespib (AUY-922) towards the Kifunensine-triggered lu...

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Publicat a:Curr Res Toxicol
Autors principals: Kubra, Khadeja-Tul, Uddin, Mohammad A., Akhter, Mohammad S., Barabutis, Nektarios
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575137/
https://ncbi.nlm.nih.gov/pubmed/33094291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crtox.2020.09.003
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