Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients

Anti-PD-1 antibodies revolutionized the treatment of advanced melanoma patients. However, one out of three do not respond to this therapy, with an overall poor prognosis. Identification of predictive biomarkers in patients receiving immune-based therapies is necessary for minimizing risk of toxicity...

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Vydáno v:Sci Rep
Hlavní autoři: Giunta, Emilio Francesco, Barra, Giusi, De Falco, Vincenzo, Argenziano, Giuseppe, Napolitano, Stefania, Vitale, Pasquale, Zanaletti, Nicoletta, Terminiello, Marinella, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, De Palma, Raffaele, Ciardiello, Fortunato, Troiani, Teresa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573589/
https://ncbi.nlm.nih.gov/pubmed/33077770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72711-2
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