Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast cancer. Here, we addressed these gaps in knowledge using two mu...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Gibson, Justin T., Orlandella, Rachael M., Turbitt, William J., Behring, Michael, Manne, Upender, Sorge, Robert E., Norian, Lyse A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573510/
https://ncbi.nlm.nih.gov/pubmed/33123173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.590794
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