Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7 and bone marrow derived macrophages (BMDMs)]...

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Publicat a:Front Immunol
Autors principals: Yang, Kun, Xu, Jingjing, Fan, Min, Tu, Fei, Wang, Xiaohui, Ha, Tuanzhu, Williams, David L., Li, Chuanfu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573489/
https://ncbi.nlm.nih.gov/pubmed/33123172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.587913
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