Amelioration of Cisplatin-Induced Ototoxicity in Rats by L-arginine: The Role of Nitric Oxide, Transforming Growth Factor Beta 1 and Nrf2/HO-1 Pathway

BACKGROUND: Cisplatin is an alkylating agent that inhibits DNA replication and interferes with proliferation of cancer cells. However, the major limiting factor for its use is the possible development of adverse effects, including ototoxicity. Up till now, the mechanisms of this ototoxicity remain p...

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Veröffentlicht in:Asian Pac J Cancer Prev
Hauptverfasser: Estfanous, Remon S, Elseady, Walaa S, Kabel, Ahmed M, Abd Ellatif, Rasha A
Format: Artigo
Sprache:Inglês
Veröffentlicht: West Asia Organization for Cancer Prevention 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573422/
https://ncbi.nlm.nih.gov/pubmed/32711445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.31557/APJCP.2020.21.7.2155
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