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Amelioration of Cisplatin-Induced Ototoxicity in Rats by L-arginine: The Role of Nitric Oxide, Transforming Growth Factor Beta 1 and Nrf2/HO-1 Pathway
BACKGROUND: Cisplatin is an alkylating agent that inhibits DNA replication and interferes with proliferation of cancer cells. However, the major limiting factor for its use is the possible development of adverse effects, including ototoxicity. Up till now, the mechanisms of this ototoxicity remain p...
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| Publicado no: | Asian Pac J Cancer Prev |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
West Asia Organization for Cancer Prevention
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573422/ https://ncbi.nlm.nih.gov/pubmed/32711445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.31557/APJCP.2020.21.7.2155 |
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