Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

BACKGROUND: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects such as nephrotoxicity and ototoxicity. Cisplatin c...

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Autori principali: Kilic, Ulkan, Kilic, Ertugrul, Tuzcu, Zeynep, Tuzcu, Mehmet, Ozercan, Ibrahim H, Yilmaz, Okkes, Sahin, Fikrettin, Sahin, Kazim
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561216/
https://ncbi.nlm.nih.gov/pubmed/23311701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-10-7
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