Gene-Environment Interaction Promotes Alzheimer’s Risk as Revealed by Synergy of Repeated Mild Traumatic Brain Injury and Mouse App Knock-In

There is a strong unmet need for translational progress towards Alzheimer’s disease (AD) modifying therapy. Unfortunately, preclinical modeling of the disease has been disappointing, relying primarily on transgenic mouse overexpression of rare dominant mutations. Clinical manifestation of AD symptom...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Chiasseu, Marius, Fesharaki, Arman, Saito, Takashi, Saido, Takaomi C., Strittmatter, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572902/
https://ncbi.nlm.nih.gov/pubmed/32858147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105059
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