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Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia
Nucleophosmin is commonly both over-expressed and mutated in acute myeloid leukemia (AML). NPM1 mutations are always heterozygous. In addition, NPM1 has a number of different splice variants with the major variant encoded by exons 1–9 and 11–12 (NPM1.1). Further variants include NPM1.2 which lacks e...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7572395/ https://ncbi.nlm.nih.gov/pubmed/33077765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73782-x |
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