Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients

OBJECTIVE: To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA and PsA. METHODS: Clinical responses and macrophage function were examined in wild-type and Tie2-overexpressing (Tie2-TG) mice in th...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Kabala, Pawel A, Malvar-Fernández, Beatriz, Lopes, Ana P, Carvalheiro, Tiago, Hartgring, Sarita A Y, Tang, Man Wai, Conde, Carmen, Baeten, Dominique L, Sleeman, Matthew, Tak, Paul P, Connor, Jane, Radstake, Timothy R, Reedquist, Kris A, García, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571483/
https://ncbi.nlm.nih.gov/pubmed/31377797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kez315
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