Upregulation of Alzheimer’s amyloid-β protein precursor in astrocytes both in vitro and in vivo

The amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that amyloid-β (Aβ) protein accumulation underlies the pathogenesis of the disease by leading to formation of β-amyloid plaques, a pathologic hallmark of AD. Aβ is a proteolytic product of β-amyloid protein precursor (AβPP; APP), whic...

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Pubblicato in:J Alzheimers Dis
Autori principali: Liang, Yingxia, Raven, Frank, Ward, Joseph F., Zhen, Sherri, Zhang, Siyi, Sun, Haoqi, Miller, Sean J., Choi, Se Hoon, Tanzi, Rudolph E., Zhang, Can
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571426/
https://ncbi.nlm.nih.gov/pubmed/32597805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200128
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