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Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously quantify hesperidin and naringenin in microsamples (100 µL) of murine plasma after intragastric administration of single pure flavonoids and a mixture. The optimi...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Araujo-León, Jesús Alfredo, Ortiz-Andrade, Rolffy, Vera-Sánchez, Rivelino Armando, Oney-Montalvo, Julio Enrique, Coral-Martínez, Tania Isolina, Cantillo-Ciau, Zulema
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7570656/
https://ncbi.nlm.nih.gov/pubmed/32947773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25184241
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