Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence

OBJECTIVE: Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside in proximity to Lgr5(+) intestinal stem cells (ISC) and mitochondria are critical for ISC-renewal and differentia...

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Vydáno v:Gut
Hlavní autoři: Khaloian, Sevana, Rath, Eva, Hammoudi, Nassim, Gleisinger, Elisabeth, Blutke, Andreas, Giesbertz, Pieter, Berger, Emanuel, Metwaly, Amira, Waldschmitt, Nadine, Allez, Matthieu, Haller, Dirk
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Inflammatory Bowel Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569388/
https://ncbi.nlm.nih.gov/pubmed/32111634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-319514
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