MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

Apoptosis and calcification of endplate chondrocytes (EPCs) can exacerbate intervertebral disc degeneration (IVDD). Mesenchymal stem cell-derived exosomes (MSC-exosomes) are reported to have the therapeutic potential in IVDD. However, the effects and related mechanisms of MSC-exosomes on EPCs are st...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Xie, Lin, Chen, Zhenhao, Liu, Ming, Huang, Weibo, Zou, Fei, Ma, Xiaosheng, Tao, Jie, Guo, Jingkang, Xia, Xinlei, Lyu, Feizhou, Wang, Hongli, Zheng, Chaojun, Jiang, Jianyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569190/
https://ncbi.nlm.nih.gov/pubmed/33230460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.09.026
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