Development and Optimization of a Hydrophobic Interaction Chromatography-Based Method of AAV Harvest, Capture, and Recovery

With many ongoing clinical trials utilizing adeno-associated virus (AAV) gene therapy, it is necessary to find scalable and serotype-independent primary capture and recovery methods to allow for efficient and robust manufacturing processes. Here, we demonstrate the ability of a hydrophobic interacti...

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Опубликовано в: :Mol Ther Methods Clin Dev
Главные авторы: McNally, David J., Piras, Bryan A., Willis, Catherine M., Lockey, Timothy D., Meagher, Michael M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2020
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569186/
https://ncbi.nlm.nih.gov/pubmed/33102619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.09.015
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