Protein Kinase C-delta Inhibition is Organ-Protective, Enhances Pathogen Clearance and Improves Survival in Sepsis

Sepsis is a leading cause of morbidity and mortality in intensive care units. Previously, we identified Protein Kinase C-delta (PKCδ) as an important regulator of the inflammatory response in sepsis. An important issue in development of anti-inflammatory therapeutics is the risk of immunosuppression...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Liverani, Elisabetta, Tursi, Sarah A., Cornwell, William D., Mondrinos, Mark J., Sun, Shuang, Buttaro, Bettina A., Wolfson, Marla R., Rogers, Thomas J., Tükel, Çagla, Kilpatrick, Laurie E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568544/
https://ncbi.nlm.nih.gov/pubmed/31908004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900897R
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