STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium

The mechanisms by which the gut luminal environment is disturbed by the immune system to foster pathogenic bacterial growth and survival remain incompletely understood. Here, we show that STAT2 dependent type I IFN signaling contributes to the inflammatory environment by disrupting hypoxia enabling...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Wilson, R. Paul, Tursi, Sarah A., Rapsinski, Glenn J., Medeiros, Nicole J., Le, Long S., Kotredes, Kevin P., Patel, Sajan, Liverani, Elisabetta, Sun, Shuang, Zhu, Wenhan, Kilpatrick, Laurie, Winter, Sebastian E., Gamero, Ana M., Tükel, Çagla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513112/
https://ncbi.nlm.nih.gov/pubmed/31009517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007745
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