Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as exposure to asbestos induces HM death. However, some asbestos-exposed HM escape cell death, accumulate DNA damage, and may become...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xue, Jiaming, Patergnani, Simone, Giorgi, Carlotta, Suarez, Joelle, Goto, Keisuke, Bononi, Angela, Tanji, Mika, Novelli, Flavia, Pastorino, Sandra, Xu, Ronghui, Caroccia, Natascia, Dogan, A. Umran, Pass, Harvey I., Tognon, Mauro, Pinton, Paolo, Gaudino, Giovanni, Mak, Tak W., Carbone, Michele, Yang, Haining
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568322/
https://ncbi.nlm.nih.gov/pubmed/32999071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007622117
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