Synergy between 15-lipoxygenase and secreted PLA(2) promotes inflammation by formation of TLR4 agonists from extracellular vesicles

Damage-associated endogenous molecules induce innate immune response, thus making sterile inflammation medically relevant. Stress-derived extracellular vesicles (stressEVs) released during oxidative stress conditions were previously found to activate Toll-like receptor 4 (TLR4), resulting in express...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ha, Van Thai, Lainšček, Duško, Gesslbauer, Bernd, Jarc-Jovičić, Eva, Hyötyläinen, Tuulia, Ilc, Nejc, Lakota, Katja, Tomšič, Matija, van de Loo, Fons A. J., Bochkov, Valery, Petan, Toni, Jerala, Roman, Manček-Keber, Mateja
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568244/
https://ncbi.nlm.nih.gov/pubmed/32973091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005111117
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